Delayed Arteriogenesis in Hypercholesterolemic Mice

Delayed arteriogenesis in hypercholesterolemic mice.

BACKGROUND Hypercholesterolemia has been reported to inhibit ischemia-induced angiogenesis. To address its effects on arteriogenesis, we investigated arterial growth in hypercholesterolemic low-density lipoprotein receptor(-/-)/ApoB-48(-/-) (HCE) mice. METHODS AND RESULTS The extent and the time course of arteriogenesis after femoral artery ligation was evaluated in HCE and strain-matched con...

Enhanced arteriogenesis and wound repair in dystrophin-deficient mdx mice.

BACKGROUND The absence of functional dystrophin in Duchenne muscular dystrophy (DMD) patients and in mdx mice results in progressive muscle degeneration associated with necrosis, fibrosis, and inflammation. Because vascular supply plays a key role in tissue repair, we examined whether new blood vessel development was altered in mdx mice. METHODS AND RESULTS In a model of hindlimb ischemia on ...

new insight in ezetimibe /garlic combination in hypercholesterolemic mice

Lentinus edodes promotes fat removal in hypercholesterolemic mice

Lentinus (L.) edodes (shiitake mushroom) is used as a traditional medicine in Asia. One of the components of L. edodes, eritadenine (an adenosine analog alkaloid), has been shown to reduce cholesterol levels. The hypocholesterolemic action of eritadenine appears to be achieved through the modification of hepatic phospholipid metabolism. In the present study, the effects of L. edodes in a mouse ...

Macrophages in Collateral Arteriogenesis

Arteriosclerotic vascular disease is the most common cause of death and a major cause of disability in the developed world. Adverse outcomes of arteriosclerotic vascular disease are related to consequences of tissue ischemia and necrosis affecting the heart, brain, limbs, and other organs. Collateral artery growth or arteriogenesis occurs naturally and can help restore perfusion to ischemic tis...